The £3.2bn ship is leading the UK Carrier Strike Group – the Royal Navy's largest deployment in more than a decade.
The vessel and her Carrier Strike Group have headed south, through the Atlantic and into the Mediterranean - stopping off in Cyprus - before sailing through the Suez Canal.
The group is visiting more than a fifth of the world's nations over 28 weeks.
It is the aircraft carrier's maiden operational deployment and she is hosting 1,700 personnel, 250 of them from the US.
What forms a Carrier Strike Group?
Protecting an aircraft carrier is a big task.
Astute-class submarines can use advanced sensors to generate a clear picture of the environment surrounding the force, feeding intelligence to other vessels from beneath the surface.
For her 2021 deployment, HMS Queen Elizabeth has F-35Bs and Royal Navy Merlin helicopters embarked.
The carrier is being escorted by Royal Navy Type 45 destroyers, Type 23 frigates, Royal Fleet Auxiliary support ships and, in the longer term, Type 26 frigates.
The group can cover 500 nautical miles in just one day and is capable of tracking up to 1,000 targets from 400km away.
The aircraft carrier also needs a replenishment ship, provided by the Royal Fleet Auxiliary.
This contains all weaponry needs, as well as food for the sailors.
In 2018, RFA Fort Rosalie delivered vital supplies to the aircraft carrier USS Theodore Roosevelt in the Arabian Gulf.
Fort Rosalie transferred 96 pallets of stores to the Roosevelt while she was with the aircraft carrier's strike group.
British personnel from RFA Fort Rosalie joined the US strike group in the Gulf.
They used the trip to see first-hand how operations are conducted aboard a US vessel, ahead of the RFA supporting the aircraft carrier HMS Queen Elizabeth.
The Queen Elizabeth-class ships will call on other vessels to support them, although it is unlikely both carriers will be deployed on operations simultaneously.
Each aircraft carrier can be deployed with up to two operational Lightning squadrons and 24 F-35Bs on board, although the maximum capacity allows for 36.
Each squadron will consist of about 12 aircraft, although for the majority of the time there could be as a few as 10 jets on board at once.
Cover image: HMS Kent and HMS Queen Elizabeth together during training at sea (Picture: Royal Navy).