In 2018, there were 125-near-misses reported between drones and aircraft - an increase of 34% from 2017.
It compares to a total of six incidents recorded in 2014.
Transport Secretary Chris Grayling said: "The UK has been consistently at the forefront of legislation to tackle drone misuse.
"All drone users should be aware that flying a drone within 5km of an airport or over 400ft is a serious criminal act, one which could put lives at risk, and risks penalties ranging from significant fines to a life sentence."
Anyone caught recklessly or negligently endangering an aircraft with a drone can be sentenced to up to five years in prison.
The intentional use of a device to commit an act of violence at an airport which could cause death, serious personal injury or endanger safe operations could result in life in prison under the Aviation and Maritime Security Act.
The Government is drafting a Drones Bill which will help the police catch those misusing the technology, including the ability to access data stored on a drone with a warrant, and stop and search powers over drone users near airfields.
Aviation Minister Liz Sugg will meet drone manufacturers to discuss how to tackle criminal misuse of their products.
The Home Office is also reviewing the UK's approach to countering the malicious use of drones.