The closure of Mildenhall has been planned for several years (Picture: US Air Force).
More than 500 members of the US Air Force and their families are to relocate from RAF Mildenhall in the next five years.
Two squadrons of personnel will move to RAF Fairford in Gloucestershire as part of the planned closure to Mildenhall.
The decision to close the Suffolk base was reportedly being reconsidered by the US Department of Defense last year.
Those moving will include members of the 95th Reconnaissance Squadron and the 488th Intelligence Squadron who will assist the United States’ RC-135 surveillance aircraft in missions.
RAF Mildenhall is currently the United States’ only European base for heavy bombers.
Announcing the move Defence Minister Tobias Ellwood said: "For more than a hundred years now our armed forces have fought in defence of our common values and interests.
"Our two countries have developed the deepest, broadest and most advanced defence relationship of any two nations.
"The agreement to relocate the United States Rivet Joint capability to RAF Fairford cements US presence at the base and will bring substantial benefits to Gloucestershire and local communities."