HMS Duncan has left Portsmouth for a six-month deployment, where she will be working alongside the French Navy.
The Type 45 frigate will be operating in the Mediterranean sea for the first part of her deployment.
She will be tasked with providing area air defence to the French aircraft carrier FS Charles de Gaulle as part of their Carrier Strike Group deployment, Groupe Aéronaval (GAN) 19.
HMS Duncan's participation in GAN 19 will offer the Royal Navy ship crucial training in task group operations and aid the preparations for HMS Queen Elizabeth's first operational deployment in 2021.
Around 280 personnel are currently onboard HMS Duncan (Picture: LPhot Corbett / via Royal Navy).
After detaching from the French Navy, she will resume NATO operations where required.
The ship's Captain Commander Tom Trent said:
"This operation with the aircraft carrier is an ideal chance to demonstrate the prime role of HMS Duncan as one of the world's most advanced destroyers.
"With HMS Queen Elizabeth almost ready for task group operations, this will be an excellent chance to prove the ability of the Type 45 as a carrier escort."
HMS Duncan will later act as a carrier escort to HMS Queen Elizabeth.
Able Seaman (AB) Bradley Stapleton, aged 19, is embarking on his first deployment with the Navy.
He said: "There is a sense of both excitement and trepidation for me as this is the first time I have been away on real operations.
"I am looking forward to the adventure ahead."
Her sister ship
HMS Dragon is currently deployed in the Gulf, where she is working with Combined Maritime Forces to protect some of the world's busiest shipping lanes and conducting counter-narcotic operations.
The destroyer's Executive Warrant Officer Martin Watson, said: "This is an exciting opportunity to work with the French aircraft carrier and there are a number of port visits to enjoy, some of which I haven't managed to visit in my 26-year career."
HMS Duncan is the sixth of the Type 45 air defence destroyers and one of the most advanced warships in the world.
She sails with a ship's company in excess of 280 personnel onboard.