Thousands of military personnel will be separated from their families during the festive period and William and Kate have flown to RAF Akrotiri on the Mediterranean island to honour their commitment.
The couple arrived bearing Christmas gifts for members of 11 Squadron, a Typhoon fighter unit based at RAF Coningsby in Lincolnshire, who fly missions from the Cyprus base to combat IS.
On Tuesday the Cambridges staged a Christmas party for families from RAF Coningsby and RAF Marham who have relatives deployed abroad, including Cyprus.
“We are really looking forward to flying to @RAFAkrotiri in Cyprus tomorrow and meeting some of the mums and dads of the little ones we have met today. I am sure they will be thrilled with all your cards and gifts, so thank you for posting them today.” – The Duchess of Cambridge pic.twitter.com/zuqksDngeb
During the event, Kate told the invited wives, partners, grandparents and children: "Not only are we grateful for you coming here to join our party, but also for the sacrifices you make on a daily basis on behalf of the nation."
A line of military dignitaries were waiting to greet the Duke and Duchess when they arrived at the Cyprus base on the RAF Voyager ministerial jet, including Akrotiri's station commander, Group Captain Chris Snaith.
During the festive period there will be 11,000 members of the British military deployed on operations.
Service personnel have been sent on 30 operations in 35 countries across the globe from Somalia and South Sudan to Kuwait and Ukraine.
Prince William is Honorary Air Commandant of RAF Coningsby in Lincolnshire, which is home to Typhoon squadrons which deploy to Cyprus and fly operations in support of Op Shader, the UK's contribution to the ongoing campaign against IS.
They work alongside 31 Squadron, a Tornado GR4 unit based at RAF Marham in Norfolk, which is also involved with the campaign.
RAF Akrotiri is the home of the Cyprus Operations Support Unit, which provides joint support to British Forces Cyprus and operations in the region to protect the UK's strategic interests.