Boris Johnson travelled to Brussels for a meeting of NATO leaders, with China and Russia two of the main issues facing the alliance.
Arriving at the Brussels summit, Mr Johnson said: "I don't think anybody around the table today wants to descend into a new Cold War with China.
"I don't think that's where people are.
"I think people see challenges, they see things that we have to manage together.
"But they also see opportunities and I think that what we need to do is do it together.”
US President Joe Biden will meet Russian President Vladimir Putin in Geneva on Wednesday and Mr Johnson said he would be taking some "pretty tough messages" to the Russian leader.
President Biden told an audience of US military personnel and service families on his meeting with Vladimir Putin, he will "let him know what I want him to know".
Boris Johnson said: "I'm always hopeful that things will improve with Russia but... I'm afraid that so far it's been pretty disappointing from the UK point of view.
"When I saw President Putin I made that very clear, I said 'Look, you know, we're ready to do things differently, we are ready to try to have closer relations but you have got to change the way you behave'.
"You'll remember what happened at Salisbury where innocent members of the public faced the poisoning from Novichok, one woman tragically lost her life.
"That's no way to behave.
"NATO allies stood by Britain then and I know that President Biden will be taking some pretty tough messages to President Putin in the course of the next few days."
Mr Johnson is expected to use the meeting to highlight the way the COVID crisis was exacerbated by security threats – including cyber attacks on the healthcare systems of some alliance members.
He will also back the modernisation programme instituted by NATO Secretary General Jens Stoltenberg, saying the alliance must be prepared to face down the challenges of the future.
Ahead of the meeting, Mr Stoltenberg said relations with Russia are at the "lowest point" since the end of the Cold War.
He said there is a "pattern of Russian behaviour" from cyber-attacks through to the willingness to use military force against neighbours such as Ukraine and Georgia.
"We see attempts to meddle in our political democratic processes, to undermine the trust in our institutions and efforts to divide us. We have to take that very seriously," he told Times Radio.
"We need to strengthen our cyber defences, we need to exchange intelligence, we need to be vigilant and aware of all these different tools of aggressive actions, military and non-military."
Meanwhile, Defence Secretary Ben Wallace suggested that former Prime Minister Theresa May would be an "excellent" candidate to succeed Mr Stoltenberg when he steps down next year.
Cover image: PA.