The RAF has airlifted more than 100 people, who had already left Afghanistan, from a neighbouring third country to the UK.
Those on board included vulnerable Afghans who qualified to come to Britain under the Afghan Relocations and Assistance Policy (ARAP), as well as British Nationals.
The flights were the first military relocation of those eligible since the end of the evacuation from Kabul – known as Operation Pitting.
Defence Secretary Ben Wallace has said "he made clear" the UK's commitment to the Afghan people "did not end" in August.
He added: "We are determined to do right by those who supported our Armed Forces for so many years and others who are at risk."
"These flights mark the beginning of what will be an enduring effort to relocate and support those who need our help."
Watch: RAF aircraft carrying 30 Afghans lands at RAF Brize Norton.
Men who served alongside British Forces in Afghanistan, but were not evacuated as part of Operation Pitting, are growing increasingly concerned about their safety and chances of surviving Taliban rule.
The UK is working with international partners to ensure as many routes as possible remain open for the movement of British nationals and relocation of ARAP-eligible Afghans.
Further flights are due to arrive in the UK in the coming weeks.
The government says when they do, eligible Afghans will be processed and supported by the Home Office and Ministry of Defence (MOD) under Operation Warm Welcome.
It says it will look to provide the support they need to rebuild their lives in Britain and includes indefinite leave to remain in the country for those under the ARAP scheme.
Operation Warm Welcome also includes funding for schooling and healthcare.