Ukrainian President Volodymyr Zelensky said Russian missiles are a challenge to Nato's collective security, as several missiles from Russia entered the airspace of Moldova.
Russia launched 70 missiles in another "massive attack", President Zelensky said in a video address to the nation on Friday evening.
According to Mr Zelensky, several of the missiles flew into Moldovan and Romanian airspace, which the Ukrainian President said was further proof that Russian aggression does not respect any borders.
Out of the 70 Russian missiles fired on Friday, 60 were shot down, according to Mr Zelensky.
"Their targets were civilians, civilian infrastructure, unfortunately, there were hits and unfortunately there are victims," he said.
"The protection of Ukraine is the protection of the whole of Europe and the world," the president added.
The Moldovan foreign ministry said it had summoned Russia's ambassador over what it called an "unacceptable violation of our airspace".
Romania has denied that Russian missiles flew into Romanian airspace.
A Romanian foreign ministry statement said it had detected an "aerial target launched from the Black Sea from a ship of the Russian Federation" but "at no point did it intersect with Romania’s airspace."
Romania has been part of the transatlantic military alliance for almost 20 years, having joined in 2004.
President Zelensky thanked everyone who has been supporting Ukraine against what he called "terrorism" from Russia.
The Ukrainian president recently made a surprise visit to the UK, before going to meet Emmanuel Macron in Paris and travelling to Brussels together with the French President.
During his address to the European Parliament in Brussels, President Zelensky reminded MEPs that Ukraine was defending Europe against Russian aggression.